Novel approaches in anticancer drug design

Dual-Target Anticancer Drug Candidates: Rational Design and Simulation Studies

This study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (TS) inhibitor. The designed scaffold is a combination of nucleobase, amino acid and aziridine structures. The candidates are docked into TS and three DNA double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

dual-target anticancer drug candidates: rational design and simulation studies

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

Novel Approaches and Assays in Drug Discovery

Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

Over the last decades, several studies have demonstrated that cancer cells have a unique metabolism compared to normal cells (Herling et al., 2011). Metabolic changes occurring in cancer cells are considered to be fundamental for the transformation of normal cells into cancer cells and are also responsible for the resistance to different types of chemotherapeutic drugs (Cree, 2011). Therefore, ...

Organic Carbamates: An Unique Linkage in Anticancer Drug Design

Organic carbamates are the stable class of compounds derived from the unstable carbamic acid having O-CO-NHlinkage [1,2] with unique applications in the field of pharmaceuticals, agrochemicals (pesticides, herbicides, insecticides, fungicides etc.), intermediates in organic synthesis, in the forms of drugs and prodrugs, for the protection of amino groups in peptide chemistry, as a useful syntho...